DETAILS, FICTION AND LDN-27219 DRUG DEVELOPMENT PIPELINE

One particular notably appealing compound is LDN-27219. Even though most tTG inhibitors are created to bind towards the protein crosslinking Lively web page, LDN-27219 alternatively binds towards the nucleotide binding pocket on the enzyme although it is in its shut-point out conformation, and stabilizes that conformation to avoid crosslinking acti